Drug combo may be effective against leukaemia (Representational Image) & nbsp | & nbspPhoto Credit: & nbspGetty Images
Washington DC: Researchers claim to have found a combination of existing drugs that can be effective against blood cancer that affects mainly older adults. Researchers tested to see if existing arsenic trioxide (ATO) was effective in combination with all-retinoic acid (ATRA) in both the mouse model and humans.
They are determined to be a combination of 'powerfully and exquisitely effective' against acute myeloid leukaemia (AML).
"There is an acute need to develop rational combinations to treat disease and overcome resistance that arises in response to therapy. By providing critical understanding of the mechanisms underlying the disease, we have identified a therapeutic strategy for treatment of this type of AML," said Pandolfi, one of the researchers.
The experiment identified key processes of cancer cells use to develop or evolve against drug in response to the study published in the Journal of Cell Research.
In addition, the team has demonstrated that a combination of drugs already used for the treatment of another type of leukemia worked equally as well as against this form of AML in both in vitro and in vivo settings.
Another form of leukaemia known as acute promyelocytic leukaemia (APL) was once a fatal diagnosis. It is now a curable disease, thanks to researchers who have demonstrated that arsenic trioxide (ATO) was effective against APL in combination with another drug called all-trans retinoic acid (ATRA).
They are determined that, while the drugs target different vulnerabilities in different forms of leukaemia, the combination performed "powerfully and exquisitely effective" against this subset of AML.