Still recovering from the death caused by the collapse of the church in KwaZulu-Natal, the mourners returning from the funeral were hit by another trauma when their bus overturned at the weekend.
The accident occurred near KwaCeza on Sunday, seriously injuring 10 people, said the provincial health department.
Forty-two others suffered minor injuries.
"We were very shocked to hear about a bus accident incident just shortly after we rested our fellow citizens who died last week in the Pentecostal Holiness Church last week. We praise the Lord for saving these lives this time," said MEC Health Dr. Sibongiseni Dhlomo.
He wished the wounded to recover quickly and praise the medical staff who treated them.
Some injuries were released from Cez and Nkonjeni hospitals, while others continue treatment.
Read: Deep Loss and Broken Heart, Named KZN Victims
On the eve of Good Friday, 13 people died during the Easter gathering in Empangeni as part of the Pentecostal church building collapsed.
This is thought to have been the result of heavy rains in the northern part of the province, KwaZulu-Natal Medical Service Emergency Spokesman Robert McKenzie said at the time.
Dhlomo said the province's pathology services have recently dealt with a number of adverse incidents.
These included the conduct of autopsies on five people who died in a Ndlagubo accident on the same day as the church collapse, and 67 people who died in special events during the devastating floods that went through eThekwini last week.
"These recent incidents have been a difficult test of our ability and readiness to respond effectively to unforeseen emergencies. Our forensic pathology, EMS rescuers, nurses, and clinicians have really come close to this opportunity in the last few days," he said.
"As sad and painful as it has witnessed the loss of lives and the destruction of property on such a massive scale, the way our people have responded is for us and for those who are grieving, yet comforting. Thank you and encourage them to continue working hard for the benefit of our fellow citizens. "