Researchers successfully succeeded in developing "mini placentas" or placental organoids that could transform pregnancy research, conception, dead birth, abortion and pregnancy diseases and disorders.
The results of the study on the development of these organoids have been published in the last issue of the journal Nature.
These organoids can successfully imitate the placenta in the early stages during the first trimester to explain to the researchers. This means that drugs or diseases that affect the placenta during this phase and lead to abortions can be studied. In fact, these tiny placentas are just like real placenta, which they can also test positively in a pregnancy test that the team explains. Ashley Moffett, senior team scientist and professor of reproductive immunology at Cambridge University, confirmed this statement: "If we put a pregnant club in the body, we read" pregnant. "
The team explains that studying the placenta in the womb has been notoriously difficult to date. A healthy placenta develops and attaches to the walls of the womb and delivers nutrients and oxygenated blood to the growing embryo and fetus. Not only does it exclude hormones and chemicals that allow the growth of the fetus, but it also excludes waste from a growing fetus. The placenta also secretes hormones into the mother's bloodstream, which helps to successfully get pregnant. These phenomena have not yet been investigated in humans. With the development of organoids, scientists can now better understand the functions and functioning of the placenta. Moffett said, "Now we can begin experimenting with how the placenta develops in the uterine environment."
The team used cells from placental tissue layers. These villas are hair like normal placental structures. These placental cells that are grown in the laboratory can be organized into multicellular clusters or structures that can act as a true placenta by secreting proteins and hormones. These are sizes from a tenth of a millimeter to half a millimeter and can be stored in frozen form only for thawing before use.
Experts in this field are looking forward to this research and said they would provide invaluable knowledge of common pregnancy disorders, including childbirth, uterine growth restriction (IUGR), and preeclampsia. Fetal infections such as Zika, and how they affect development and growth, could also be investigated.
Research leader Margherita Turco said in her statement: "Placenta is absolutely essential to support the baby because it grows inside the mother. If it does not work properly, it can result in serious problems, from pre-eclampsia to abortion, with immediate and life-long consequences for mother and child. "The team adds that it would also be invaluable when testing teratogenic drugs or medications to damage the unborn baby when given to a mother. Placental organoids could also be the source of stem cell therapies for failing or at risk of pregnancy, which the team explains. In short, there are several uses of these organoids in pregnancy research.
According to Moffett, "It took 30 years before we reached this point and we had mini-placentas that we know grow in the lab for at least a year."
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