Proposed stem cells in the patient's brain



Japanese scientists have given so-called "IPS" stem cells to the brain of a patient with Parkinson's disease. The aim of this clinical trial is to verify whether these cells can regenerate dopamine neurons and release symptoms.

TeamKyoto University injection of 2.4 million of them pluripotent cellscapable of giving any type of cell on the left brain, during the three-hour operation last month. The man at his age of fifty was well tolerated and will now be under surveillance for two years, the Kyoto University said in a statement.

If there is no problem in the next six months, the researchers then implant another 2.4 million cells, this time into the right part of the patient's brain. These iPS cells from healthy donors should grow neurons dopamine producer, a neurotransmitter involved in engine management.

In July, Kyoto University announced this clinical trial with seven participants aged 50-69. "I greet patients for their courageous and decisive participation", said Professor Jun Takahashi, quoted the public television channel NHK on Friday.

Pluripotent cells generate new neurons

Parkinson's disease is marked by degeneration of dopamine neurons and results symptoms which are gradually getting worse, such as tremors, limb stiffness and reduced body movements. This affects more than ten million people around the world, according to Parkinson's disease US. Therapies are currently available "Improving Symptoms without Delaying Progression of Disease"explains the foundation.

This test follows a monkey experiment stem cells of human origin that have improved the ability to move primates who are suffering from Parkinson's disease, according to a study published in the end of August 2017 in a scientific journal nature, Survival of transplanted cells by priming brain injections was observed for two years, with no tumor,

induced pluripotent stem cells (iPS for induced pluripotent stem cells), adult cells are brought back to an almost embryonic state by expressing them in four genes (normally inactive in adult cells). This genetic manipulation gives them the ability to produce any kind cell (pluripotency), depending on the body where they are transplanted. The use of iPS cells does not represent basic ethical problems, unlike stem cells embryos people.

What to remember

  • Researchers from Kyoto University have given 2.4 million pluripotent cells to the brain of the patient.
  • These cells from healthy donors will have to regenerate dopamine neurons.
  • Overall, a clinical study should include seven patients.

Parkinson's disease: The stem cells in monkeys return disease

Article from Tokyo – AFP released on February 25, 2012

Monkey evolving the equivalent Parkinson's disease showed an improvement in their symptoms after injection of human stem cells into their brains. This technique could be tested in humans since 2015.

Monkeys suffering from Parkinson's disease have made significant progress after implanting human stem cells into their brains, Central European scientists said.

Four monkeys whose limbs moved spasmodically (a common symptom syndrome from ParkinsonAnd whoever tried to control his body showed signs of improvement three months after surgery, said Jun Takahashi, a professor atKyoto University, one of the authors of the study published in Journal of Parkinson's disease,

Six months after transplantationfour test primates were again able to walk in their cage, he added.

June Takahashi said that at the time of implementation, 35% stem cells were dopaminergic neurons, and about a tenth of them still lived a year later. In order to improve the effectiveness of the treatment, he would like to increase this survival to 70%. He hopes he will be able to carry out this experiment on humans as early as 2015. " First, we need to increase the number of dopaminergic neurons implantto reduce the risk tumor " post-operative, he explained.

Pluripotent stem cells induced in humans

In a monkey experiment, Jun Takahashi and his team used it embryonic stem cellsbut in the case of medical experience, scientists think they use it induced pluripotent stem cells (IPSC), created by implanting four types of genes into human skin cells for reprogramming. These induced iPSCs, which are thus generated, return to almost the embryonic phase (undifferentiated).

Use embryonic stem cells, which is considered very promising by many scientists, is against. Religious groups regard the culture of these cells as unethical, which emphasizes destruction of the embryoHowever, there is nothing in Japan to prevent the use of these cells for scientific research.

Parkinson's disease is one of the main ones neurodegenerative diseasesafter Alzheimer's diseaseIt is also one of the most common causes of motor impairment accident cerebrovascular disease.

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