The experimental influenza product, molnupiravir, has shown surprisingly good results
A new antiviral drug, called MK-4482 / EIDD-2801, or molnupiravir can completely stop coronavirus transmission within 24 hours, according to a study by the Institute of Biomedicine at the University of Georgia. It is an experimental influenza drug that has recently been developed but has proven to be a “side effect” and an effective countermeasure against COVID-19.
“This is the first example of an oral drug that quickly blocks the transmission of SARS-CoV-2 and can change the rules of the game,” the researchers said in a publication in the journal Nature Microbiology.
To control COVID-19 and to mitigate the catastrophic effects of a pandemic, it is essential to prevent the mass transmission of the virus until reliable vaccines are developed. However, because molnupiravir is taken orally, treatment can be started at an early stage, which facilitates its effectiveness in three ways: by suppressing the development of infection into severe phases; shortening the infectious phase and consequently reducing the emotional and economic consequences of long-term isolation of the patient; rapid suppression of local outbreaks.
“We have previously found that MK-4482 / EIDD-2801 has a wide range of activities against respiratory RNA viruses and that oral treatment of infected animals with this drug reduces the number of viruses spread by several orders of magnitude, which drastically reduces their transmission. properties have made MK-4482 / EIDD / 2801 a strong candidate for pharmacological control of COVID-19, “the researchers wrote.
They used molnupiravir on ferrets because they think these small predators are a good model for research because they “spread SARS-CoV-2 easily, but many do not develop a serious disease that is very similar to SARS-CoV-2 spread. “. CoV-2 in young people ”.
According to Joseph Wolf of Plemper Laboratory and one of the study’s authors, the procedure was as follows: The team infected the ferrets with coronavirus and then treated them with molnupivir. During treatment, infected ferrets were released into healthy animals and no cases of infection transmission were reported. At the same time, ferrets treated with this drug developed a placebo rapidly and recovered.