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Study: Early lipids boost brain growth for vulnerable micro-preemies – (Details)

Dietary lipids, also an important source of energy for tiny preemies, also provide a much-needed brain boost by significantly increasing the global brain volume as well as increasing the volume in the regions involved in motor activities and memory, according to the research presented during the Pediatric Academic Societies 2019 Annual Meeting.

"Compared with macronutrients like carbohydrates and proteins, lipid intake during the first month of life is associated with increased overall and regional brain volume," says Catherine Limperopoulos, Ph.D. Children's National and Senior Author. “Using non-invasive magnetic resonance imaging, we see increased volume in the cerebellum by 2 weeks of age. And at four weeks of life, lipids increase total brain volume and boost regional brain volume in the cerebellum, amygdala-hippocampus and brainstem. ”

The cerebellum is involved in virtually all physical movement and enables coordination and balance. The amygdala processes and stores short-term memories. The hippocampus manages emotion and mood. And the brainstem acts like a router, passing messages from the brain to the rest of the body, as well as enabling essential functions like breathing, and steady heart rate and swallowing.

According to the Centers for Disease Control and Prevention, about 1 in 10 U.S. Pat. babies is born preterm, or before 37 weeks gestation. Regions of the brain that play vital roles in complex cognitive and motor activities exponential growth late in pregnancy, making developing brains of preterm infants particularly vulnerable to injury and impaired growth.

Children 's research faculties examined the impact of lipid intake in the first month of life on very low birth weight infants, who weighed 1,500 grams or less at birth. These micro-preemies are especially vulnerable to growth failure and neurocognitive impairment after birth.

The team enrolled 68 micro-preemies who were 32 weeks of gestational age and younger when they were admitted to Children’s neonatal intensive care unit during their first week of life. They measured cumulative macronutrients – carbohydrates, proteins, lipids and calories – consumed by these newborns at 2 and 4 weeks of life. Over years, Limperopoulos' has a large database of babies who were born full-term; This data provides unprecedented insights into normal brain development and will help advance understanding of brain development in high-risk preterm infants.

"Even after controlling for average weight gain and other health conditions, lipid intake was positively associated with cerebellar and brainstem volumes in very low weight preterm infants," adds Katherine M. Ottolini, the study's lead author.

According to Limperopoulos, Children 's future research will examine the optimal timing and volume of lipids to boost neurodevelopment for micro – preemies.

Katherine M. Ottolini, lead author; Nickie Andescavage, M.D., Attending, Neonatal-Perinatal; Kushal Kapse, research and development staff engineer and co-author; and Catherine Limperopoulos, Ph.D., Director of MRI Research of Developing Brain and Senior Author, All of Children's National.


Children’s National Health System. .

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