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How to treat 8 children with HIV



United States researchers say they used HIV to create gene therapy that cured 8 children with severe combined immunodeficiency, commonly known as "bubble babies".

The research results that were developed at Tennessee Hospital in the United States have been published in a journal New England Journal of Medicine,

Children who have been born with little or no immunity now have immune systems that function normally,

Children suffering from this condition and not receiving treatment must live in a fully sterilized environment and usually die as children.

Per month

Genetic therapy included the acquisition of bone marrow from children and children fix a genetic defect in your DNA shortly after his birth.

The "correct" gene – used to correct the defect – was inserted into the changed version HIV, virus that causes AIDS.

Scientists say most children were released every month.

Ewelina Mamcarz from St. Jude Hospital and co-author of the study said: “These patients are now children who respond to vaccines and have an immune system to create all the immune cells they need to protect themselves from infections when they explore the world. and lead a normal life.

"This is a milestone for SCID-X1 patients," he added, referring to the most common type of SCID (severe combined immunodeficiency).

Patients were treated at St. Patrick's Hospital Jude in Memphis and UCSF Benioff Children's Hospital in San Francisco.

What is SCID Syndrome?

Case David Vetter he is perhaps best known from this disease that prevented him from interacting with the outside world outside his plastic camera.

Vetter was born in 1971 with this disease and died at the age of 12 after the failure of a bone marrow transplant.

Within 20 seconds of being born at a Texas Children's Hospital in Houston, he was placed in the building insulating chamber plastic, where he lived until he was 6, when he could leave with a plastic suit specially designed by NASA.

His parents had already lost their baby because of the disease before he was born.

What other treatment options exist?

It is currently the best treatment a bone marrow transplant from a compatible donor,

According to St. However, more than 80% of these patients do not receive a compatible donor and must receive stem cells from the blood of other donors.

This process is less likely to cure the disease and more likely to cause serious side effects as a result of treatment.

Previous advances in gene therapy have offered alternatives to bone marrow transplantation, but this treatment sometimes included chemotherapy and had implications for a variety of other diseases, including blood disorders, sickle cell anemia and thalassemia and metabolic syndrome.



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