WASHINGTON, March 15, 2019 / PRNewswire / – An article published in Experimental Biology and Medicine (Volume 244, Issue 3, February 2019) (https://journals.sagepub.com/doi/pdf/10.1177/1535370219829006) describes a new model of heart valve physiology. A study conducted by Dr. Carla Lacerda, from the Department of Chemical Engineering at. t Texas Tech University in Lubbock, TXThe US reports that 10% of the cyclic radial strain on the anterior leaflets of the isolated mitral valve provides a real physiological environment that can be used to study the mechanism and discovery of drugs.
Heart valves are responsible for maintaining a smooth blood flow in one direction. It is estimated that more than 5 million Americans live with a dysfunctional heart valve. Mechanical stresses (tensile and shear forces) are the main cause of valve degeneration. Valvular endothelial cells, one of the two types of heart valve-containing cells, can protect the valves from degeneration. Understanding the molecular mechanisms that these cells use to respond to stress will provide new targets for the treatment of valvular disease.
In the current study, Dr. Lacerda and colleagues used proteomic analysis to evaluate the effect of a 10% cyclic radial strain on isolated heart valves. Stretch downregulated cytoskeletal proteins and proteins involved in energy metabolism, indicating a quiescent state. Endothelial removal resulted in downregulation of the extracellular matrix and cellular matrix adhesive proteins, suggesting a protective role for the endothelium in extracellular matrix homeostasis. Endothelial removal also increases protein synthesis activity. Together, these studies provide new insights into molecular mechanisms that regulate heart valve response to mechanical tension. These studies also define the true physiological environment that can be used to study valvular function as well as to discover new drugs for preventing, slowing, or reversing valvular disease. Dr. Lacerda said that "the development of in vitro models for the proper management of replacement tissue design is key to the development of tissue engineering techniques." Only by developing physiologically-mimic constructs in which cells behave in the same way as in vivo, will we be able to understand the molecular mechanisms that cells use to defend themselves against environmental insults.
Dr. Steven R. Goodman, Editor-in-Chief Experimental Biology and Medicine"Lacerda and colleagues provide proteomic and interactive analysis of proteins and protein networks affected by mechanical mitral valve expansion and / or endothelium. This will be a useful platform for future studies of cardiac valve pathophysiology."
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SOURCE Experimental Biology and Medicine