Researchers from CNRS, University of Caen Normandy, Paris-Est Créteil University and OTR3 are working on a new approach to helping stroke victims, a treatment that would restore sensory and stroke engine lost.
In France, approximately 150,000 people suffer each year. Stroke is the main cause of acquired disability in adults and the second leading cause of death in France.
Most of these strokes are caused by a cerebral artery closure by a blood clot. The only way to prevent neurons from dying because they are deprived of oxygen is to remove this clot. This surgery is only possible in the first hours after the stroke, which can only treat a minority of patients.
In the face of this, the team led by CNRS researcher Myriam Bernaudin, decided to explore a new path, and was interested in a cellular environment, also called an extracellular matrix. The matrix serves as cell support. When a stroke occurs, it breaks the matrix, which amplifies neuronal death.
A team of researchers put into the rat an agent similar to the components that structure the cell matrix. This post-stroke injected agent proved to be effective because it allowed for the protection and reconstitution of the matrix that had been affected. This device has also helped to support the development of new neurons and to promote the restoration of sensory and motor functions.
For the time being tested only on rats, this promising track should be the subject of pilot clinical trials by the end of 2019.