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parts of the brain change before the first symptoms

Scientists have tried to understand the difference between the changes our brain undergoes during its natural aging and when it is affected by Alzheimer's disease. By consulting thousands of MRI, they found some parts of the brain atrophied.

CNRS researchers, Ecole Pratique des Hautes Etudes (EPHE) and the University of Valencia (Spain) analyzed more than 4,000 MRI of "healthy" Alzheimer's brains and brains to understand the difference between natural brain aging and disease-related development.

Before the first signs

Our brain is evolving throughout lifefrom our birth to our death. Some diseases, including Alzheimer it changes our brain. Therefore, scientists decided to compare 4000 MRI of the brain understand how a healthy brain evolves and especially what age changes can be seen between normal aging trajectory and brain changes Alzheimer's disease,

For the purpose of the study, they consulted 2944 MRI healthy controls (ranging from several months to 94 years). This allowed them to create a "normal" model progress of the brainCNRS researchers compared it to the average pathological model. The latter was determined from MRI of 1385 patients over 55 years of age and 1877 young controls.

40 years

Researchers found, after comparison with MRI subjects with Alzheimer's disease older than 55 years early divergence pathological models compared to normal aging trajectory. Scientists have done it hippocampus, the change was found before the age of 40 and about 40 years for amygdala. These areas of the brain atrophy when they are affected by Alzheimer's disease.

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CNRS researchers, the Ecole Pratique des Hautes Etudes and the University of Valencia also found that brain cavities in patients with Alzheimer's disease, the so-called lateral ventricles are often expanded earlier.

brain cavities it is involved in the secretion and circulation of cerebrospinal fluid in which the central nervous system is bought out. In particular, the interest in this discovery seems to be limited because the same things have been found in healthy individuals whose brains age normally.

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