Thursday , March 21 2019
Home / korea / "Brain estrogen reduces bone production 8 times ↑" … Treatment of osteoporosis "blue light"

"Brain estrogen reduces bone production 8 times ↑" … Treatment of osteoporosis "blue light"



Studies have shown that lowering estrogen secretion in the brain's hypothalamus can significantly increase the production of healthy bones.

The findings, co-written by scientists at the University of California at Los Angeles (UCLA) and the University of California at San Francisco (UCSF), are published in the recent issue of Nature Communications.

There is currently no osteoporosis treatment and the outcome should be a milestone in the development of therapeutic drugs.

According to the Centers for Disease Control and Prevention (CDC), one fourth of US women aged 65 or over are osteoporosis.

Researchers looked at estrogen, a type of sex hormone that is not known to work in the brain.

Specifically, we have focused on the function of cerebral neural hypothalamic cells with high estrogen sensitivity.

The hypothalamus, which connects the nervous system of the brain and the endocrine system, helps control body temperature, hunger, sleep and fatigue and plays an important role in metabolism.

Estrogen in the blood promotes bone growth, but in the brain the hypothalamus has the opposite function.

When the estrogen receptor was removed from the arcuate nucleus of the experimental rats, the rats were weighed and became less active.

At first I thought fat and muscle tissue had increased, but in later surveys, it was found that weight gained in increasing bone volume.

Some rats increased bone volume by 800%.

When I used this method in rats with severe osteoporosis who lost 70% of bone volume, I recovered my bone density by 50% within a few weeks.

As bone density increases, the bones become very heavy at the same time.

Leading author report and professor of molecular molecular pharmacology, Dr. Holling Ghulham, says that the current knowledge of bone growth control can not explain the findings and suggests new treatments for older women and patients with weak bones I thought I found a way.

The team intends to focus on the core of the hypothalamus, which appears to have an effect on bone strengthening.

Scientists state that these cells can use the energy and resources needed to grow bones to other parts of the body.

Interestingly, this phenomenon occurs only in female mice in this experiment.

Dr. Inggham has shown that it is unlikely that this could be detected because most neuroscientists tested only male mice, and if the fact that the brain sends circulatory factors that promote bone growth is a real opportunity to develop osteoporosis therapies.


Source link