Discovery: The block of "happiness hormone" activates immune cells



Clinical use against autoimmune diseases, allergies and cancer

"autoimmune disease and allergies are among the most common emerging diseases worldwide and therapies are urgently needed. Here ours discovery to be extremely useful. if yes BH4 inhibits a constant way of attacking these autoaggressive T cells, thus not destroying healthy tissue or causing chronic inflammation, "he said. Shane Cronin, Postdoc on IMBA and the first author of the current publication in nature,

Together with

Clifford Woolf from the Boston Children's Hospital Harvard and Kai Johnsson, Max Planck The Institute of Medical Research, Heidelberg, researchers have developed a new drug called QM385, BH4 inhibits and immune cells with exaggerated exaggerated reactions. First clinical trials are in operation.

BH4 also for cancer therapies?

BH4 At the same time, it is also an important candidate for future cancer immunotherapy because activated T cells detect and fight against cancer cells. Researchers found in mice that BH4 T cells help target the tumor. It also turned out to be the emergence BH4 can be blocked by kynurenin, a molecule that immune system it can turn off tumors. Gift BH4 let T cells grow again.

Valuable knowledge of relationships

"Knowledge of new biology and disease relationships is particularly valuable, as applications can be very versatile. Who would think it's ours? immune system a controlled molecule known from neurobiology and possibly new applications autoimmune diseaseAsthma can even lead to cancer and immunodeficiency! "He said Shane Cronin,
"If one can find the interconnection of different biological systems in the body, as in this case the nervous system and immune system, sometimes you can be amazing discoveries do". In the past, the team is around Josef Penninger Using the example of the RANKL signaling pathway, bone metabolism and the hormonal system could be combined. Denosumab drug therapy ranges from bone loss to pill for breast cancer, currently

Austria is being tested.


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