Actually, Nadine Spuhler, 26, wanted to go shopping for a short time after work and then had a nice evening with her boyfriend – but then everything changed. "Suddenly I did not feel the right half of my body," says a young woman. "And I did not get the money from my purse to buy."
It did not improve during the evening; on the contrary: "I could not stand or walk, my friend had to take me to the emergency room at the nearest hospital." From there, it was a blue light at the University Hospital in Basel, where it had to be left for a more detailed explanation,
It is also called multiple sclerosis as "a disease with thousands of faces".
In November 2016, the diagnosis was confirmed: multiple sclerosis (MS). It is a chronic inflammatory disease of the central nervous system, ie the brain and the spinal cord, which affects especially young adults. Triggers are inflammations of the medullar nerve fibers. These lesions or lesions cause the messages are not properly transmitted from the muscles, organs or other parts of the body to the brain – or vice versa.
Symptoms may vary considerably depending on where the changes occur, from sight and mood disorders to muscle paralysis and blistering problems. Therefore, MS is also called "disease with thousands of faces".
Early diagnosis is important
As with Nadine Spuhler, it is difficult to diagnose, especially because other illnesses often have more symptoms. Additionally, symptoms may fall off at all stages of the disease or even remain one-off.
"Diagnosis is first determined by a variety of neurological tests and MRIs that show the central nervous system," explains Jens Kuhle, a neurologist and head of the MS Center at Basel University Hospital. There are also other diagnostic procedures such as cerebrospinal fluid examination, cerebrospinal fluid.
"Many patients with RS have normal life after a year of illness."Jens Kuhle, neurologist
"Early diagnosis is important in any case because pharmacotherapy can, in the vast majority of cases, positively influence the course of the disease or stop it," says the expert. But when is the doctor's visit unavoidable? "If neurological disorders such as vision problems, limb numbness, walking weakness and do not disappear within 24 hours, you should contact a family doctor or a neurologist and refer the patient to a specialized center if necessary."
Fear from the wheelchair
The diagnosis was a shock to Nadine Spuler. How long will she still be able to practice her physiotherapist? Could she have children? "I thought I'd have to spend my life in a wheelchair soon." In fact, this idea persists, but: "That's certainly not the case," says Jens Kuhle. "There are a lot of people with MS who have available medication that is now available to work very well and cause the disease to be relatively mild – many patients with MS are still able to walk for years and decades after the onset of the disease and live normal life."
MS is still untreatable. While there was no therapy available 25 years ago, there are now approximately 15 re-treatable drugs. The first drug has been approved for those with primary progressive MS, PPMS abbreviated in the meantime. In this form of MS, where neurological deficits and physical disability are increasing slowly and insidiotically – ie without relapse – there are no specific drugs. With ocrelizumab, patients now also have access to a proven drug.
How does a drug work? Multiple sclerosis is one of the so-called autoimmune diseases. In this way, the body's own defense mechanisms, instead of foreign body substances, are falsely directed against their own tissues. In MS, some cells attack the brain and the spinal cord and destroy nerve tissue. This may lead to the symptoms described earlier.
According to recent research, a certain group of immune cells, B-cells, play an important role. New MS drugs are able to attack these cells. So-called monoclonal antibodies, such as ocrelizumab, can specifically specifically interfere with this disease. "They recognize B lymphocytes in the blood and destroy them," explains Jens Kuhle. "Thus, the number of lesions, ie Brain Damage, may be reduced and disease progression can be slowed down."
That's how I can temporarily forget the disease. "Nadine Spuhler *, Affected
Several weeks after her first difficult rendition, Nadine Spuhlerová suffered two more. She first prescribed medical tablets and from March 2018 she received newly approved monoclonal antibodies. These are infused at six-month intervals. With Nadine Spuler, they have a lasting effect, and since the beginning of the treatment there have been no complaints about MS.
"If I had to take pills daily, the illness would be present all the time, but I can forget it sometimes," he says. This is also because there have been no side effects, such as upper respiratory tract infections, since the start of treatment. He says, "It makes me feel secure."
* Name modified by the content management system
Created: 31.01.2019, 20:16 hours