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Can not sleep well overnight, toxic brain protein has increased by 50%: Insomnia can support Alzheimer's disease |



Scientists have long known that poor quality sleep is associated with the onset of Alzheimer's disease, but little is known as insomnia speeds up brain damage. Now the key mechanism of the Washington University Medical School team has emerged. If the evening does not rest, the Tau protein content in the brain increases overnight and can accumulate in the clusters over a long period of time, a precursor to brain damage.

Progression of Alzheimer's disease is related to the deposition of amyloid beta and Tau protein into the brain. Both sticky plaques can kill nerve cells and affect memory. With the ability to perform.

Last year, a study of 20 healthy adults showed that only night sleep, beta amyloid content in the brain dramatically increased, especially in the right hippocampus associated with the onset of Alzheimer's disease (right Hippocampus) and thalamus.

Now, a research team at the University of Washington Medical School has found that insomnia overnight also causes a tangible increase in tau content in the brain by 50%.

Tau protein is found in the brain of healthy people, but under certain conditions, Tau proteins begin to aggregate and create neurofibrillary spleen in nerve cells, causing collapse of microtubules in nerve cells, and the transport system of the cytoskeleton collapses. Bad causes communication failure between chemical messages between nerve cells and ultimately leads to the death of nerve cells.

So-called "certain conditions" probably involve insomnia.

A new study carried out two experiments on mice and humans, the mice were divided into two groups, one group was sleeping in normal physiological time, and the other group was awakened daily all the time. Another Tau protein was found in the brain of mice and entangled with fibers, and the area of ​​accumulation was the same as for Alzheimer's disease.

In experiments on humans, Brendan Lucey, an assistant professor of neuropatology, received two cerebrospinal fluid from eight subjects: one was omitted from normal sleep and the other was omitted after sleep all night, just after measurement. It was found that overnight could cause a 50% increase in protein content Tau in the brain.

Both experimental studies have shown that tau often relaxes during waking and cleanses during sleep. When you sleep well, this cycle is interrupted, causing accumulation of tau proteins and may begin to accumulate in harmful fibers.

As more and more research points to the positive link between poor sleep quality and Alzheimer's disease, it comes to the conclusion that sleep at night should protect your brain. The new post was published in the journal Science.

(Source: pixabay)

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