Los Blancos had a turbulent start to the season.
In the struggle against Julen Lopetegui, they competed in the home.
Santiago Solari, after acting as an administrator, has made reins permanently.
Isco was an important player during Zinedine Zidane's term of office.
However, a talented player slid down the massive order.
According to Spanish journalist Eduard Indy, the cards are moving to West London or Etihad.
He said OK Diario: "They think Isco is not interested in the group that he is doing his thing, he has problems with his weight … so he thinks he will go to the Premier League.
"He has an offer from Chelsea and others from Pep Guardiola in Manchester.
"I think in a game style like City, it could do very well.
"Cristiano Ronaldo did not like him because he said he played a lot."
Isco received 252 players in real time when he joined the Malaga club in 2013.
Chelsea has more than expected Maurizio Sarri.
Real, however, remains enthusiastic about Eden Hazard, who has been repeatedly linked to the Bernabeu switch.
Isco could be used as an improved contract for the Belgian international concern, as Real seems to conceal its ultimate goal.
Blues legend Dennis Wise thinks Hazardu's departure is inevitable at some point.
"He's obviously an ambitious guy, and if he wants to be the world's top high-end player, he'll probably have to go ahead and fight a bunch of different things," Wise Express told Sport.
"You have Barcelona and Real Madrid – these are the places where the top players want to end.
"But at the moment it's important that we still get him at Chelsea and I think he loves it.
"I'm sure he will decide in time what is best for him.
"At the end of the day he is a world-class player and at the start of this season he has made a difference.
"You want to lose him? Of course not, it's irreplaceable if I'm honest.
"One day, unfortunately, when he wants to go, he will.
"Let's hope we have some more seasons."
Real are in sixth position in La Liga – although there are only four points outside Barcelona's flywheels.
Then, after an international break, they meet a trip to the Basque mines of Eibar.