Students at the University of Nottingham will be able to use software for training in a modern drug discovery, thanks to collaboration with the Optibrium software developer.
Optibrium's StarDrop software is available to a number of 4th year MSc students in the field of chemistry at the University to help them train in a modern drug discovery. In particular, the software will be used to support the design of potential new compounds to inhibit integrin in fibrotic diseases and malaria as part of collaboration with GSK.
Optibrium also teaches students about the use of drug discovery software and helps them prepare for a career in the pharmaceutical industry.
This software will help students characterize the properties of known drugs, understand structure-activity relationships in existing project data, and design new candidate compounds using predictive models.
Almost half of the world's population is estimated to be at risk of malaria, and in 2015 the disease was responsible for 445,000 deaths. The World Health Organization has set a plan to reduce malaria and death by 90% by 2030. There is concern about resistance to antimalarial treatments, increasing the need for new drugs to treat and blocking malaria transmission.
Fibrotic diseases are caused by the build up of a scar in the extracellular matrix of certain organs, particularly kidney, liver, lung and skin. Students at the University of Nottingham will study inhibition of integrin and will feel the tissue of the scar causing the disease.
Dr. Matthew Segall, Optibrium CEO, said: "Our partnership with the University of Nottingham gives us the opportunity to work with students and give them access to cutting-edge technology for drug discovery. Fibrotic diseases and malaria continue to cause significant mortality and morbidity and are therefore pleased to help prepare future medical pharmacies and work together to find therapeutic and preventive treatment. "
Thomas McInally, a scientist in the field of Medicinal Chemistry at GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, said: "Teaching professional skills and giving students access to the latest technology is critical to developing the next generation of successful drug-discovery scientists. this goal by providing access to its world-class StarDrop software and extensive expertise in medical chemistry. "