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Diet capsules that swell in the stomach could help weight loss life and style



A gel capsule that partially fills the stomach before eating can help people lose weight and keep it away, the European Obesity Congress has been said on Sunday.

The Hydrogen Capsule first released news in 2010 when it was called Attiva. Now, as Plenita, it has been tested on over 400 people. Only 59% of people worked, but in these cases they doubled their chances of losing 5% -10% of their body weight.

Slimming pills have a rich history, and only one is approved for use in the UK's NHS – Xenical – which is not very popular due to its mode of operation. It stops fat absorption so it passes through the body and can cause stomach or intestinal problems.

The fullness of the American company Gelesis is technically a medical device rather than a medicine, so it does not need such extensive experiments. The capsules contain a hydrogel made from cellulose found in fruits and vegetables, and citric acid. Two capsules are taken with two glasses of water 20 minutes before a meal. They absorb water and swell in the stomach.

"What happens is that these small particles are released in the stomach and turned into a gel. This gel occupies about 250 ml of stomach – about a quarter of its volume, "said Dr. Harry Leider, Chief Medical Officer of Gelesis.

“This gel – like chewed vegetables – mixes with food. This makes you feel fuller when you eat, so you don't eat so much. This is the main mechanism. "

The gel is not absorbed. It goes through the small intestine, then reaches the large intestine where it breaks down, the water reabsorbs, and what's left is escaping in the stool.

“Since there is no chemical interaction with the body, it is not absorbed, it is mostly mechanical. He has a really good safety and tolerance profile, ”he said. "That's why it's regulated as a means and not as a cure.

“It is recommended that it be help in weight loss in conjunction with diet and exercise. We encourage patients to contribute carefully to the diet and focus on exercise because we know that it will help people be successful. Nothing is a silver bullet. This is a new tool in our armory. "

The study included 436 subjects, half of whom took capsules while the other half had placebo. They were all overweight or moderately obese and trying to lose weight through diet and exercise. The average weight at the beginning was about 100 kg 15st 10 lb). Those in the placebo group lost 4.4% of their body weight and those who took active capsules lost 6.4%. But considering the differences, including initial weight, age, and gender, Leider said that there was a 2% weight loss over placebo.

Obesity experts have said that capsules could be useful, which could be available in pharmacies next year.

"I would like to warn against magical charges, but for a certain group of consumers who do everything right in terms of diet and exercise, it can help keep them on the road," said Professor. Jason Halford of Liverpool University at a meeting in Glasgow where the results of the trials were presented.

“That could be a huge help to millions of people. It is well tolerated and increases saturation, so people eat less. You don't need a surgeon, just buy it in a box and swallow the pill. It seems to be easy and effective, so millions could benefit, "said Dr. Kurt. Nathalie Farpour-Lambert, President of the European Association for the Study of Obesity.

However, Professor Helen Stokes-Lampard, chairwoman of the Royal College of General Practitioners, was cautious. "That certainly sounds like an interesting development, and the non-invasive nature of the pill would be attractive to many patients and healthcare professionals," she said.

"We must point out, however, that it is a new miracle cure for weight loss, because non-medical approaches to healthy lifestyles should always be explored in the first instance so that they do not become dependent on medical devices as a society. intervention. "


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