An international team headed by the University of Miami (UM) and the National Institute of Health and Medical Research (INSERM) France has discovered five new genes that increase the risk of suffering from Alzheimer's disease by comparing and analyzing genetic data of over 94,000 people,
Except genes O genetic mutations IQCK, ACE, ADAM10, ADAMTS1 and WWOX, researchers found how the existence of specific gene changes associated with the & quot; tau & quot; may affect the progression of the disease at an earlier stage than previously assumed.
According to UM, "these findings support the idea that groups of genes associated with specific biological processes work together with the control of functions that affect the development of the disease."
Before this study identified about 20 genes associated with Alzheimer's disease, Said Margaret Pericak-Vance, co-author of the research paper. WITH the discovery of five other genes opens "new and fascinating ways of research" and "the development of new medicines in the future".
The results of the study, the largest of those conducted to date to find the underlying causes of Alzheimer's disease, were published this Thursday in a journal Genetics of nature
The data used has gathered four large groups participating in the International Alzheimer's Genome Project (IGAP).
Brian Kunkle, A scientist at the John S. Hussman Institute for Human Genome (HIHG), part of the UM Miller School of Medicine, stressed that sharing scientific data brings "impressive" results. "The ability to combine data from many research groups has allowed us to find new connections to the causes of Alzheimer's disease," he added.
Besides Kunkle's study, Margaret Pericak-Vance, director of HIHG, and French Benjamin Grenier-Boley and Jean-Charles Lambert of INSERM conducted the study. "It's a fascinating time to study Alzheimer's disease, which is the most common cause of dementia in older people," Pericak-Vance said. "These genes contain instructions for using the body and we are now getting a better understanding of how Alzheimer's guidelines are read, which is the first step to transferring this knowledge to the area of clinical care," he added.
The National Institute of Aging (NIA) and other entities integrated into the National Institutes of Health of the United States. They have partly funded this study, which suggests that treatment developed for early onset of Alzheimer's disease may also work in people whose disease begins later.
"Given that the combined effect of genes can dramatically change each gene acting alone, genomics researchers are dedicated to exploring not only what the physical instruction manuals are, regardless of how these instructions are interconnected and affect the environment , "says UM.
As soon as the functions of the five new Alzheimer-associated genes are understood and examined in conjunction with other genetic genes that are the risk factors for this disease, scientists will have a better attitude to find out where the genetic "mushrooms" of Alzheimer's disease are grouped, .
With this knowledge, researchers can look for genetic "nodes" to discover the mechanisms of the disease and the potential goals of drugs to treat them.
Studies also reveals that rare mutations, as they are known to account for less than 1% of the population, they appear to have "an important role in Alzheimer's disease".
Researchers have discovered this finding by common mutations associated with Alzheimer's disease that affect more than 1 percent of the population and those rare are usually found in the same genes or genetic groups.
Although some rare mutations were previously associated with the risk of suffering from Alzheimer's disease, it is the first time that it is known that there is much more than previously thought and that it is more likely than it was assumed to be in the same genes and "hubs" variants.
"The identification and confirmation of these rare mutations will be an important step forward in creating personalized strategies and developing greater knowledge about Alzheimer's," UM said.